Animal models of sepsis
نویسندگان
چکیده
منابع مشابه
Animal models of sepsis
Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to define adequately. Despite its importance as a public health problem, efforts to develop and gain regulatory approval for a specific therapeutic agent for the adjuvant treatment of sepsis have been remarkably unsuccessful. One step in the critical pathway for the development of a new agent for adjuvant trea...
متن کاملAnimal Models for Sepsis Research
Edison P Reyes1,2, Paula P Cortés3 and Ricardo Fernández3* 1Centro de Fisiología Celular e Integrativa, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo, Chile 2Dirección de Investigación, Universidad Autónoma de Chile, Chile 3Departamento de Salud, Universidad de Los Lagos, Chile *Corresponding author: Ricardo Fernández, Departamento de Salud, Universidad de Los Lagos. Av. Fuch...
متن کاملAnimal models of sepsis and sepsis-induced kidney injury.
Sepsis is characterized by a severe inflammatory response to infection, and its complications, including acute kidney injury, can be fatal. Animal models that correctly mimic human disease are extremely valuable because they hasten the development of clinically useful therapeutics. Too often, however, animal models do not properly mimic human disease. In this Review, we outline a bedside-to-ben...
متن کاملThe disconnect between animal models of sepsis and human sepsis.
Frequently used experimental models of sepsis include cecal ligation and puncture, ascending colon stent peritonitis, and the i.p. or i.v. injection of bacteria or bacterial products (such as LPS). Many of these models mimic the pathophysiology of human sepsis. However, identification of mediators in animals, the blockade of which has been protective, has not translated into clinical efficacy i...
متن کاملAnimal models of sepsis: setting the stage.
Sepsis is a state of disrupted inflammatory homeostasis that is often initiated by infection. The development and progression of sepsis is multi-factorial, and affects the cardiovascular, immunological and endocrine systems of the body. The complexity of sepsis makes the clinical study of sepsis and sepsis therapeutics difficult. Animal models have been developed in an effort to create reproduc...
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ژورنال
عنوان ژورنال: Virulence
سال: 2013
ISSN: 2150-5594,2150-5608
DOI: 10.4161/viru.26083